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[牛白血病遗传学中的问题。II. 父母对后代白血病发病频率的影响]

[Problems in the genetics of bovine leukemia. II. The effect of fathers and mothers on the leukemia disease frequency in the progeny].

作者信息

Ernst L K, Petukhov V L

出版信息

Genetika. 1978;14(7):1247-56.

PMID:669261
Abstract

Geneology of 14,000 animals which are the progeny of 554 bulls are studied, 2060 of them having leucosis. Differences between bulls in the frequency of the disease in daughters are observed. The morbidity of daughters of bulls having leucosis is higher than for the population in the average. The morbidity of the animals depends on the linear relation animals. "Leucosis" families having a high concentration of ill animals for several generations, and families resistant to leucosis are revealed. Daughters of leucosis mothers got ill more often than those of healthy animals. The coefficient of heritability of leucosis ranges from 0.07 to 0.50. Concordancy for leucosis in unisexual twins is 74.1%. Insignificant increase in leucosis is found for the last three generations. Predisposition for leucosis is characterized by a complex hereditary condition. The portion of genetic factors is quite enought to conduct the animal selection for leucosis resistance.

摘要

对14000只动物(它们是554头公牛的后代)的谱系进行了研究,其中2060只患有白血病。观察到公牛女儿中疾病发生频率的差异。患有白血病的公牛的女儿的发病率高于总体平均水平。动物的发病率取决于线性关系动物。发现了几代患病动物高度集中的“白血病”家族以及对白血病因具有抗性的家族。患白血病母亲的女儿比健康动物的女儿患病更频繁。白血病的遗传力系数在0.07至0.50之间。单性双胞胎中白血病的一致性为74.1%。在过去三代中发现白血病有不显著的增加。白血病的易感性以复杂的遗传状况为特征。遗传因素的比例足以进行抗白血病动物的选择。

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