遗传性癫痫易感性大鼠中单胺能受体的评估。
Evaluation of monoaminergic receptors in the genetically epilepsy prone rat.
作者信息
Ko K H, Dailey J W, Jobe P C
出版信息
Experientia. 1984 Jan 15;40(1):70-3. doi: 10.1007/BF01959107.
The intensity of sound-induced convulsions in the genetically epilepsy-prone rat (GEPR) was reduced in a dose related fashion by intracerebroventricular administration of dobutamine, (beta 1 agonist), terbutaline (beta 2 agonist) or phenylephrine (alpha 1 agonist). BHT-920 (alpha 2 agonist) did not cause a dose-related decrease in sound-induced convulsion intensity. Binding studies showed that whole brain alpha and beta receptor densities (Bmax) were normal while the Kd was increased for the beta ligand in GEPR brain.
通过脑室内注射多巴酚丁胺（β1激动剂）、特布他林（β2激动剂）或去氧肾上腺素（α1激动剂），遗传性癫痫易感大鼠（GEPR）中声音诱发惊厥的强度呈剂量依赖性降低。BHT - 920（α2激动剂）并未导致声音诱发惊厥强度出现剂量依赖性降低。结合研究表明，GEPR脑内全脑α和β受体密度（Bmax）正常，而β配体的解离常数（Kd）增加。
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