Feustel P J, Stafford M J, Allen J S, Severinghaus J W
J Appl Physiol Respir Environ Exerc Physiol. 1984 Jan;56(1):150-4. doi: 10.1152/jappl.1984.56.1.150.
The H2 clearance technique was used to determine the blood flow of the postulated respiratory chemosensitive areas near the ventrolateral surface of the medulla. In 12 pentobarbital sodium-anesthetized cats, flow (mean +/- SD) was measured from 25-micron Teflon-coated platinum wire electrodes implanted to a depth of 0.3-0.7 mm. Flow (in ml X min-1 X 100 g-1, n = 35) was 52.8 +/- 28.5 in hypocapnia [arterial CO2 partial pressure (PaCO2) = 21.8 +/- 1.6 Torr], 57.8 +/- 27.5 in normocapnia (PaCO2 = 31.9 +/- 2.2 Torr), and 75.0 +/- 31.7 in hypercapnia (PaCO2 = 44.5 +/- 3.0 Torr). Flow determined from 15 electrodes in adjacent pyramidal tracts (white matter) was less at all levels of CO2; 22.9 +/- 12.3 in hypocapnia, 29.1 +/- 15.9 in normocapnia, and 33.9 +/- 13.9 in hypercapnia. In hypoxia [arterial O2 partial pressure (PaO2) = 39.9 +/- 6.3 Torr] ventrolateral surface flow rose to 87.9 +/- 47.6, and adjacent white matter flow was 35.8 +/- 15.6. These results indicate that flow in the postulated central chemoreceptor areas exceeds that of white matter and is sensitive to variations in PaCO2 and PaO2.
采用H2清除技术测定延髓腹外侧表面附近假定的呼吸化学敏感区域的血流量。在12只戊巴比妥钠麻醉的猫中，用植入深度为0.3 - 0.7毫米的25微米涂有聚四氟乙烯的铂丝电极测量血流量（平均值±标准差）。低碳酸血症[动脉血二氧化碳分压（PaCO2）= 21.8±1.6托]时血流量（以毫升·分钟-1·100克-1为单位，n = 35）为52.8±28.5，正常碳酸血症（PaCO2 = 31.9±2.2托）时为57.8±27.5，高碳酸血症（PaCO2 = 44.5±3.0托）时为75.0±31.7。在相邻锥体束（白质）中15个电极测定的血流量在所有二氧化碳水平下均较低；低碳酸血症时为22.9±12.3，正常碳酸血症时为29.1±15.9，高碳酸血症时为33.9±13.9。在低氧血症[动脉血氧分压（PaO2）= 39.9±6.3托]时，腹外侧表面血流量升至87.9±47.6，相邻白质血流量为35.8±15.6。这些结果表明，假定的中枢化学感受器区域的血流量超过白质，并且对PaCO2和PaO2的变化敏感。
