Tollefson G, Lesar T, Herzog C
J Clin Psychiatry. 1984 Jan;45(1):31-3.
Atrial flutter developed in an 80-year-old woman after 10 days of treatment with maprotiline at therapeutic concentrations. This cardiac irregularity is extremely rare with the conventional antidepressants. Evidence is reviewed to suggest that the likely mechanism was reuptake blockade of noradrenergic amines stimulating reentrant excitation within the atria.
一名80岁女性在接受治疗浓度的马普替林治疗10天后出现心房扑动。这种心脏节律异常在传统抗抑郁药中极为罕见。现回顾相关证据表明，其可能机制是去甲肾上腺素能胺的再摄取阻断，从而刺激心房内的折返性兴奋。
