Maekawa T, Tommasino C, Shapiro H M
J Cereb Blood Flow Metab. 1984 Mar;4(1):88-95. doi: 10.1038/jcbfm.1984.11.
Local cerebral blood flow (LCBF) was evaluated with the [14C]iodoantipyrine quantitative autoradiographic technique in 29 brain structures in conscious control rats and during fentanyl-induced electroencephalographic (EEG) spike and/or seizure activity and in the postseizure EEG suppression phase. During spike activity, LCBF increased in all structures; the increase reached statistical significance (p less than 0.05) in the superior colliculus, sensorimotor cortex, and pineal body (+130%, +187%, and +185% from control, respectively). With progressive development of seizure activity, LCBF significantly increased in 24 brain structures (range, +58% to +231% from control). During the postseizure EEG suppression phase, LCBF remained elevated in all structures (+80% to +390% from control). The local cerebrovascular resistance (LCVR) significantly decreased in 10 of 29 structures with the onset of spike activity (range, -24% to -64%), and remained decreased in all brain structures during seizure activity (range, -34% to -67%) and during the EEG suppression phase (range, -24% to -74%). This reduction of LCVR represents a near maximal state of cerebrovasodilation during fentanyl-induced EEG seizure or postseizure suppression activity. The global nature of the LCBF elevation indicates that factors other than local metabolic control are responsible for CBF regulation during local seizure activity.
采用[¹⁴C]碘安替比林定量放射自显影技术，在清醒对照大鼠的29个脑结构中，以及在芬太尼诱发脑电图（EEG）棘波和/或癫痫活动期间及癫痫发作后EEG抑制期，评估局部脑血流量（LCBF）。在棘波活动期间，所有结构的LCBF均增加；上丘、感觉运动皮层和松果体的增加具有统计学意义（p<0.05）（分别比对照增加130%、187%和185%）。随着癫痫活动的进展，24个脑结构的LCBF显著增加（范围为比对照增加58%至231%）。在癫痫发作后EEG抑制期，所有结构的LCBF仍保持升高（比对照增加80%至390%）。随着棘波活动的开始，29个结构中有10个结构的局部脑血管阻力（LCVR）显著降低（范围为-24%至-64%），在癫痫活动期间（范围为-34%至-67%）和EEG抑制期（范围为-24%至-74%），所有脑结构的LCVR均保持降低。这种LCVR的降低代表了芬太尼诱发EEG癫痫发作或癫痫发作后抑制活动期间脑血管舒张的近乎最大状态。LCBF升高的全局性表明，在局部癫痫活动期间，除了局部代谢控制之外的因素负责CBF调节。
