小鼠组织淀粉样蛋白AA。与两种血清淀粉样蛋白（ApoSAA）基因产物之一仅在氨基末端具有序列同一性。
Murine tissue amyloid protein AA. NH2-terminal sequence identity with only one of two serum amyloid protein (ApoSAA) gene products.
作者信息
Hoffman J S, Ericsson L H, Eriksen N, Walsh K A, Benditt E P
出版信息
J Exp Med. 1984 Feb 1;159(2):641-6. doi: 10.1084/jem.159.2.641.
Abstract
Amyloid protein AA is the presumptive fragment of an acute phase serum apolipoprotein, apoSAA. Two major murine apoSAA isotypes (apoSAA1 and apoSAA2) have been identified. The NH2-terminal amino acid sequences of purified murine apoSAA1 and apoSAA2 have been examined and compared with that of murine amyloid protein AA. Our results indicate that apoSAA1 and apoSAA2 are separate gene products and that amyloid protein AA has NH2-terminal amino acid sequence identity with only one of these isotypes, namely apoSAA2.
摘要
淀粉样蛋白AA被推测为急性期血清载脂蛋白apoSAA的片段。已鉴定出两种主要的小鼠apoSAA同种型（apoSAA1和apoSAA2）。对纯化的小鼠apoSAA1和apoSAA2的氨基末端氨基酸序列进行了检测，并与小鼠淀粉样蛋白AA的序列进行了比较。我们的结果表明，apoSAA1和apoSAA2是不同的基因产物，并且淀粉样蛋白AA仅与其中一种同种型（即apoSAA2）具有氨基末端氨基酸序列同一性。
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