Garcia J, Smith F R, Cucinell S A
J Pediatr. 1984 Feb;104(2):268-70. doi: 10.1016/s0022-3476(84)81010-0.
Urinary D-lactate excretion, expressed as the molar D-lactate/creatinine ratio, was measured serially in nine term and premature infants with necrotizing enterocolitis, 15 healthy term infants, and eight term and premature infants sick but without NEC. The mean (+/- SD) uDL/CR of the infants with NEC was 1.63 +/- 1.09, significantly greater than the mean uDL/CR of the healthy infants (0.16 +/- 0.04) or the sick infants without NEC (0.43 +/- 0.32). The uDL/CR of infants with NEC rose coincident with the onset of disease, reached peak values at an average of 5.8 days, and subsided to baseline levels on recovery. Seven of the nine infants with NEC reached or exceeded a peak uDL/CR of 1.47; no infant without NEC reached this ratio. We conclude that uDL/CR is increased in infants with NEC and demonstrates the increased enteric bacterial activity in this disease.
以摩尔D-乳酸/肌酐比值表示的尿D-乳酸排泄量，在9例患有坏死性小肠结肠炎的足月儿和早产儿、15例健康足月儿以及8例患病但无坏死性小肠结肠炎的足月儿和早产儿中进行了连续测量。坏死性小肠结肠炎患儿的平均（±标准差）尿D-乳酸/肌酐比值为1.63±1.09，显著高于健康婴儿（0.16±0.04）或无坏死性小肠结肠炎的患病婴儿（0.43±0.32）。坏死性小肠结肠炎患儿的尿D-乳酸/肌酐比值随疾病发作而升高，平均在5.8天时达到峰值，并在恢复时降至基线水平。9例坏死性小肠结肠炎患儿中有7例达到或超过了1.47的尿D-乳酸/肌酐比值峰值；无坏死性小肠结肠炎的婴儿均未达到该比值。我们得出结论，坏死性小肠结肠炎患儿的尿D-乳酸/肌酐比值升高，表明该疾病中肠道细菌活性增加。
