Schieffer G W, Palermo P J, Pollard-Walker S
J Pharm Sci. 1984 Jan;73(1):128-31. doi: 10.1002/jps.2600730136.
An isothermal chromatographic (GC) method employing an SE-30 column and flame-ionization detection has been developed for the simultaneous assay of methyl, ethyl, propyl, and butyl 4-hydroxybenzoates and 4-hydroxybenzoic acid in liquid antacid formulations. The method, which uses a silica column chromatographic cleanup step prior to GC, is specific for the compounds with respect to possible degradation products, impurities, and excipients.
已开发出一种采用SE - 30柱和火焰离子化检测的等温色谱（气相色谱，GC）方法，用于同时测定液体抗酸剂制剂中的甲基、乙基、丙基和丁基对羟基苯甲酸酯以及对羟基苯甲酸。该方法在进行气相色谱分析之前使用硅胶柱色谱净化步骤，对于可能的降解产物、杂质和辅料而言，该方法对这些化合物具有特异性。
