Hagen P T, Scholz D G, Edwards W D
Mayo Clin Proc. 1984 Jan;59(1):17-20. doi: 10.1016/s0025-6196(12)60336-x.
The incidence and size of the patent foramen ovale were studied in 965 autopsy specimens of human hearts, which were from subjects who were evenly distributed by sex and age. Neither incidence nor size of the defect was significantly different between male and female subjects. The overall incidence was 27.3%, but it progressively declined with increasing age from 34.3% during the first three decades of life to 25.4% during the 4th through 8th decades and to 20.2% during the 9th and 10th decades. Among the 263 specimens that exhibited patency in our study, the foramen ovale ranged from 1 to 19 mm in maximal potential diameter (mean, 4.9 mm). In 98% of these cases, the foramen ovale was 1 to 10 mm in diameter. The size tended to increase with increasing age, from a mean of 3.4 mm in the first decade to 5.8 mm in the 10th decade of life.
在965份人类心脏尸检标本中研究了卵圆孔未闭的发生率和大小，这些标本来自性别和年龄分布均匀的受试者。男性和女性受试者的缺损发生率和大小均无显著差异。总体发生率为27.3%，但随着年龄增长逐渐下降，从生命最初三十年的34.3%降至第四至八十年的25.4%，再降至第九和第十十年的20.2%。在我们研究中显示通畅的263个标本中，卵圆孔的最大潜在直径为1至19毫米（平均4.9毫米）。在98%的这些病例中，卵圆孔直径为1至10毫米。其大小倾向于随着年龄增长而增加，从第一个十年的平均3.4毫米增加到生命第十个十年的5.8毫米。
