Tu W H, Petitti D B, Biava C G, Tulunay O, Hopper J
Nephron. 1984;36(2):118-24. doi: 10.1159/000183130.
By univariate analysis of patients with membraneous nephropathy, terminal renal failure was associated with male sex, a large amount of proteinuria, low serum albumin concentration, low creatinine clearance rate, high serum creatinine concentration, and high systolic blood pressure, but was not associated with age or prednisone treatment. In a multivariate life table analysis that controlled for all these factors simultaneously, the risk of developing terminal renal failure was significantly independently associated only with sex, serum albumin concentration, and prednisone treatment, being higher in men, lower in those treated with prednisone, and inversely related to serum albumin. Except for the minimal electron-dense deposition, the electron microscopic findings had no predictive value.
通过对膜性肾病患者进行单因素分析，终末期肾衰竭与男性、大量蛋白尿、低血清白蛋白浓度、低肌酐清除率、高血清肌酐浓度和高收缩压相关，但与年龄或泼尼松治疗无关。在同时控制所有这些因素的多变量生存表分析中，发生终末期肾衰竭的风险仅与性别、血清白蛋白浓度和泼尼松治疗显著独立相关，男性风险更高，接受泼尼松治疗者风险更低，且与血清白蛋白呈负相关。除了最小电子致密沉积外，电子显微镜检查结果无预测价值。
