[体外及对过敏反应的抑制作用 1-甲基-3-异丁基黄嘌呤]
[In vitro and inhibition of anaphylactic reactions 1-methyl-3-isobutylxanthine].
作者信息
Gushchin I S, Bogush N L, Sviridov V V
出版信息
Biull Eksp Biol Med. 1977 Apr;83(4):443-6.
PMID:66950
Abstract
1-methyl-3-isobutylxanthine (MIBX), a potent antiphosphodiesterase drug, inhibited the anaphylactic reactions both in vitro and in vivo: anaphylactic histamine release from the isolated mast cells of rats, anaphylactic contracture of the isolated trachea of guinea pigs, passive cutaneous anaphylaxis (PCA) in mice and anaphylactic bronchial constriction (ABC) in guinea pigs. MIBX inhibited the anaphylactic reaction of the trachea, PCA and ABC more than the corresponding reactions induced by histamine.
摘要
1-甲基-3-异丁基黄嘌呤（MIBX）是一种强效抗磷酸二酯酶药物，在体外和体内均能抑制过敏反应：抑制大鼠分离肥大细胞的过敏组胺释放、豚鼠分离气管的过敏挛缩、小鼠的被动皮肤过敏反应（PCA）以及豚鼠的过敏性支气管收缩（ABC）。与组胺诱导的相应反应相比，MIBX对气管、PCA和ABC的过敏反应抑制作用更强。
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