Punnen S, Gonzalez E R, Krieger A J, Sapru H N
Pharmacol Biochem Behav. 1984 Jan;20(1):85-9. doi: 10.1016/0091-3057(84)90106-0.
Cardiac vagolytic effect of four commonly used neuromuscular blockers, (viz. D-tubocurarine, decamethonium, pancuronium and gallamine) was compared in midcollicular decerebrate rats. The intravenous doses of neuromuscular blockers used (d-tubocurarine: 0.1 mg/kg; decamethonium: 2 mg/kg; pancuronium: 0.1 mg/kg; gallamine: 20 mg/kg) were sufficient to produce the paralysis of respiratory muscles. Bradycardia was induced by electrical stimulation of the vagus or by injecting dimethyl-phenyl-piperazinium (DMPP; a ganglionic stimulant). It was observed that d-tubocurarine and decamethonium were devoid of cardiac vagolytic action. On the other hand, pancuronium and gallamine inhibited significantly the bradycardia induced by electrical stimulation of the vagus or injection of DMPP; gallamine was found to have greater vagolytic action. The pressor responses to DMPP were not attenuated by pancuronium and gallamine indicating that in the dose administered, these agents did not block the ganglia. Bradycardia induced by the administration of acetylcholine in the left atrium was also attenuated by pancuronium and gallamine suggesting that the drugs produce cardiac vagolytic action by acting on the post-synaptic cholinergic receptors of the heart.
在中脑去大脑大鼠中比较了四种常用神经肌肉阻滞剂（即筒箭毒碱、十烃季铵、泮库溴铵和加拉明）的心脏迷走神经阻滞作用。所使用的神经肌肉阻滞剂的静脉注射剂量（筒箭毒碱：0.1毫克/千克；十烃季铵：2毫克/千克；泮库溴铵：0.1毫克/千克；加拉明：20毫克/千克）足以导致呼吸肌麻痹。通过电刺激迷走神经或注射二甲基苯基哌嗪鎓（DMPP；一种神经节兴奋剂）诱导心动过缓。观察到筒箭毒碱和十烃季铵没有心脏迷走神经阻滞作用。另一方面，泮库溴铵和加拉明显著抑制电刺激迷走神经或注射DMPP所诱导的心动过缓；发现加拉明具有更强的迷走神经阻滞作用。泮库溴铵和加拉明并未减弱对DMPP的升压反应，这表明在所给药剂量下，这些药物并未阻断神经节。泮库溴铵和加拉明也减弱了通过在左心房注射乙酰胆碱所诱导的心动过缓，这表明这些药物通过作用于心脏的突触后胆碱能受体产生心脏迷走神经阻滞作用。
