II期酶诱导降低了大鼠体内七氯的负荷。
Phase II enzyme induction reduces body burden of heptachlor in rats.
作者信息
Rozman K K
出版信息
Toxicol Lett. 1984 Jan;20(1):5-12. doi: 10.1016/0378-4274(84)90176-0.
PMID:6695396
Abstract
Contrary to expectations hexadecane had no significant effect on the body clearance of heptachlor in rats. However, phase II enzyme induction altered the kinetics of heptachlor dramatically, reducing its half-life by about 3-fold. The reduction of half-life was reflected in correspondingly lowered adipose tissue and blood levels.
摘要
与预期相反，十六烷对大鼠体内七氯的清除没有显著影响。然而，II 相酶诱导显著改变了七氯的动力学，使其半衰期缩短了约 3 倍。半衰期的缩短相应地反映在脂肪组织和血液水平的降低上。
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