Gitel'man L G, Klimenkov A A, Tkacheva G A
Vopr Onkol. 1984;30(1):52-6.
Blood plasma levels of carcino-embryonic antigen in 128 patients and 50 healthy subjects were measured radioimmunologically. A significant increase was not registered until stage III of the disease. Peak level of carcino-embryonic antigen level was at stage IV. The concentration dropped rapidly after a complication-free radical surgery. A dynamic follow-up established an increase in the level of the antigen in cases of recurrences and metastases. The concentration rose, on the average, 3.5 months prior to development of the first clinical symptoms.
采用放射免疫法测定了128例患者和50名健康受试者的血浆癌胚抗原水平。直到疾病Ⅲ期才出现显著升高。癌胚抗原水平的峰值出现在Ⅳ期。在进行无并发症的根治性手术后，其浓度迅速下降。动态随访发现，复发和转移病例中抗原水平升高。平均而言，在出现首个临床症状前3.5个月，浓度开始上升。
