Rosenberg L, Miller D R, Kaufman D W, Helmrich S P, Stolley P D, Schottenfeld D, Shapiro S
Am J Epidemiol. 1984 Feb;119(2):167-76. doi: 10.1093/oxfordjournals.aje.a113735.
The risk of breast cancer in relation to oral contraceptive use was evaluated in a case-control study of 1191 patients with breast cancer and 5026 control patients. For ever-use compared with never-use, the estimated relative risk of breast cancer was 1.0 (95% confidence interval 0.9-1.2). Use of oral contraceptives for five or more years was not associated with breast cancer, regardless of whether use had ended as much as 10 or more years previously, or more recently. Within categories of women whose baseline risk was elevated, including nulligravidae, premenopausal women, and those with benign breast disease or history of breast cancer in first-degree relatives, the relative risk estimates for five or more years of oral contraceptive use approximated 1.0. For any use before first pregnancy, the relative risk estimate was 1.3, and for use lasting three or more years it was 0.9. These data suggest that long-term oral contraceptive use does not increase the risk of breast cancer even after a latent interval in excess of one decade; nor do oral contraceptives appear to increase the risk within categories of women at relatively high baseline risk.
在一项针对1191例乳腺癌患者和5026例对照患者的病例对照研究中，评估了口服避孕药与乳腺癌风险之间的关系。与从未使用过口服避孕药相比，曾经使用过口服避孕药的患者患乳腺癌的估计相对风险为1.0（95%置信区间为0.9 - 1.2）。使用口服避孕药五年或更长时间与乳腺癌无关，无论使用结束时间是在10年或更久之前，还是更近。在基线风险较高的女性类别中，包括未生育女性、绝经前女性以及患有良性乳腺疾病或一级亲属有乳腺癌病史的女性，使用口服避孕药五年或更长时间的相对风险估计值约为1.0。对于首次怀孕前的任何使用情况，相对风险估计值为1.3，而使用持续三年或更长时间的相对风险估计值为0.9。这些数据表明，长期使用口服避孕药即使在超过十年的潜伏期后也不会增加患乳腺癌的风险；口服避孕药在基线风险相对较高的女性类别中似乎也不会增加风险。
