Albert D M, McGhee C N, Seddon J M, Weichselbaum R R
Am J Ophthalmol. 1984 Feb;97(2):189-96. doi: 10.1016/s0002-9394(14)76089-1.
In the first well-documented case of bilateral retinoblastoma to be cured by X-irradiation of the nonenucleated eye, a basal cell carcinoma and then a squamous cell carcinoma of the eyelids developed 60 years after the original treatment. The patient, a 66-year-old man, had been treated by Verhoeff between 1917 and 1919. These new tumors may have been examples of second primary tumors, found in about 0.5% to 2.5% of patients with bilateral retinoblastoma, or they may have been coincidental. Because of the 60-year period between the patient's original treatment and the development of these tumors, it seems unlikely that they were the result of the irradiation.
在首例有充分记录的通过对未摘除眼球进行X射线照射治愈双侧视网膜母细胞瘤的病例中，在最初治疗60年后，眼睑出现了基底细胞癌，随后又出现了鳞状细胞癌。该患者为一名66岁男性，于1917年至1919年间接受了韦尔霍夫的治疗。这些新肿瘤可能是双侧视网膜母细胞瘤患者中约0.5%至2.5%出现的第二原发性肿瘤的实例，也可能是巧合。由于从患者最初治疗到这些肿瘤出现间隔了60年，它们似乎不太可能是放疗的结果。
