类风湿关节炎的长期低剂量糖皮质激素治疗与骨质疏松症
Prolonged low-dose corticosteroid therapy and osteoporosis in rheumatoid arthritis.
作者信息
Hajiroussou V J, Webley M
出版信息
Ann Rheum Dis. 1984 Feb;43(1):24-7. doi: 10.1136/ard.43.1.24.
Abstract
Thirty-one patients with rheumatoid arthritis maintained on prednisolone 5 mg daily for an average period of 9.4 years were assessed radiologically to determine the degree of osteoporosis in their spine and peripheral skeleton. They were compared with a control group of 32 rheumatoid patients who had never received corticosteroids. The steroid-treated patients had more severe osteoporosis than the controls, though the difference was not statistically significant. In the female patients the spine appeared to be more sensitive than the peripheral skeleton to the osteoporotic effect of corticosteroids.
摘要
对31例类风湿性关节炎患者进行了放射学评估，以确定其脊柱和外周骨骼的骨质疏松程度。这些患者平均每日服用5毫克泼尼松龙，持续9.4年。将他们与32例从未接受过皮质类固醇治疗的类风湿性关节炎患者组成的对照组进行比较。尽管差异无统计学意义，但接受类固醇治疗的患者骨质疏松比对照组更严重。在女性患者中，脊柱似乎比外周骨骼对皮质类固醇的骨质疏松作用更敏感。
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