Kennedy A C, Smith D A, Anton H C, Buchanan W W
Scand J Rheumatol. 1975;4(4):209-15. doi: 10.3109/03009747509165258.
Osteoporosis was studied in 307 patients with "definite" or "classical" rheumatoid arthritis by measurement of the clavicular cortical thickness (C.C.T.). Bone loss, as measured by this index, fell with advancing age, and was significantly greater than in non-rheumatoid control subjects matched for age and sex. Bone loss from the clavicles was not greater in patients treated with corticosteroid drugs. Loss of bone from the clavicle correlated with osteoporosis in other parts of the skeleton, as determined by the femoral and metacarpal indices. This suggests that osteoporosis in rheumatoid arthritis is a generalised phenomenon rather than a localised process secondary to adjacent joint inflammation.
通过测量锁骨皮质厚度（C.C.T.），对307例患有“明确”或“典型”类风湿性关节炎的患者进行了骨质疏松症研究。以此指标衡量，骨质流失随年龄增长而下降，且显著高于年龄和性别相匹配的非类风湿性对照受试者。接受皮质类固醇药物治疗的患者，其锁骨骨质流失并不更多。由股骨和掌骨指数测定，锁骨骨质流失与骨骼其他部位的骨质疏松症相关。这表明类风湿性关节炎中的骨质疏松症是一种全身性现象，而非继发于相邻关节炎症的局部过程。
