Jimenez S A, Millan A, Bashey R I
Arthritis Rheum. 1984 Feb;27(2):180-5. doi: 10.1002/art.1780270209.
Abnormalities in collagen metabolism similar to those occurring in the skin of patients with scleroderma have been demonstrated in the TSK (tight skin) mouse, a dominant mutant of the inbred B10.D2(58N)/SN mouse strain. These abnormalities, which consist of increased collagen content, accelerated biosynthesis, and increased extractibility of the newly synthesized molecules, suggest that the TSK mouse may be an excellent animal model for the study of the connective tissue alterations characteristic of scleroderma.
在近交系B10.D2(58N)/SN小鼠品系的显性突变体TSK（紧皮）小鼠中，已证实其胶原代谢异常与硬皮病患者皮肤中出现的异常相似。这些异常包括胶原含量增加、生物合成加速以及新合成分子的可提取性增加，这表明TSK小鼠可能是研究硬皮病特征性结缔组织改变的优秀动物模型。
