Tolmachev V S, Borovitskaia E I, Semchenkova S A, Kushch A A, Zelenin A V
Biull Eksp Biol Med. 1984 Feb;97(2):181-3.
The authors studied the properties of peripheral blood lymphocyte chromatin from donors (non-pregnant women), from women with normal pregnancy and during threatened abortion. Using three independent cytochemical methods that characterize the DNA accessibility for acridine orange and 3H-actinomycin D and the presence in histones of free amino groups, it has been established that lymphocyte chromatin from women during threatened abortion is repressed to a greater degree than in those with normal pregnancy. The data presented demonstrate the prospectiveness of the use of the cytochemical tests for chromatin properties with a purpose of diagnosing whether the pregnancy will be full-term and treatment control.
作者研究了来自捐献者（非孕妇）、正常妊娠女性以及先兆流产女性外周血淋巴细胞染色质的特性。通过三种独立的细胞化学方法来表征吖啶橙和3H-放线菌素D对DNA的可及性以及组蛋白中游离氨基的存在情况，已证实先兆流产女性的淋巴细胞染色质比正常妊娠女性的受到更大程度的抑制。所呈现的数据表明，利用染色质特性的细胞化学检测来诊断妊娠是否能足月及进行治疗监测具有前瞻性。
