消炎痛对二甲基肼预处理大鼠结肠癌的促进作用
Enhancement of colonic cancer by indomethacin treatment in dimethylhydrazine pretreated rats.
作者信息
Danzi M, Ferulano G P, Abate S, Califano G
出版信息
Carcinogenesis. 1984 Feb;5(2):287-9. doi: 10.1093/carcin/5.2.287.
PMID:6697445
Abstract
Indomethacin treatment to rats bearing dimethylhydrazine-induced colonic cancer resulted in increased mortality (p less than 0.01) and a greater incidence of metastases compared to untreated animals with the same stage of disease. It is postulated that indomethacin might have a promotional effect on the spread of autochthonous experimental colon cancer.
摘要
对携带二甲基肼诱导的结肠癌的大鼠进行吲哚美辛治疗，与处于相同疾病阶段的未治疗动物相比，死亡率增加（p小于0.01）且转移发生率更高。据推测，吲哚美辛可能对自发性实验性结肠癌的扩散具有促进作用。
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