在两栖动物粗皮渍螈血浆中鉴定出两种血红蛋白结合蛋白。
Two hemoglobin-binding proteins identified in the plasma of the amphibian Taricha granulosa.
作者信息
Francis R T, Becker R R
出版信息
Comp Biochem Physiol B. 1984;77(2):341-7. doi: 10.1016/0305-0491(84)90341-9.
PMID:6697692
Abstract
The plasma of the amphibian newt Taricha granulosa has been shown to be devoid of haptoglobin. Upon hemolysis, Taricha albumin and another protein associate with hemoglobin. The acute-phase response to inflammation observed in birds and mammals appears to be absent in Taricha. Taricha hemoglobin failed to bind to human haptoglobin. Taricha hemoglobin not only failed to dissociate into alpha beta dimers as did human Hb, but formed alpha beta octamers.
摘要
已证明两栖动物粗皮渍螈的血浆中缺乏触珠蛋白。溶血后，粗皮渍螈白蛋白和另一种蛋白质与血红蛋白结合。在鸟类和哺乳动物中观察到的对炎症的急性期反应在粗皮渍螈中似乎不存在。粗皮渍螈血红蛋白无法与人触珠蛋白结合。粗皮渍螈血红蛋白不仅不像人类血红蛋白那样解离成αβ二聚体，反而形成了αβ八聚体。
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