Lewis R W, Garcia R R
Fertil Steril. 1984 Mar;41(3):465-9. doi: 10.1016/s0015-0282(16)47729-0.
The purpose of this 6-month study was to see whether azoospermia could be produced by injection of sclerosing agents into the cauda epididymides. Three groups of monkeys had bilateral cauda epididymides injections with (1) 0.5 ml of 4% formalin in glycerol, (2) 0.5 ml of methylcyanoacrylate (MCA), or (3) 100 mg of quinacrine hydrochloride in 2 ml of saline. Failure rates were very high in the formalin and quinacrine groups (60% and 75%, respectively). Three animals given quinacrine died unexpectedly. In the MCA group the failure rate was 40%. Local tissue reaction to the sclerosing agent was minimal with MCA, compared with the other two agents.
这项为期6个月的研究旨在观察向附睾尾部注射硬化剂是否会导致无精子症。三组猴子双侧附睾尾部注射了：（1）0.5毫升4%福尔马林甘油溶液；（2）0.5毫升氰基丙烯酸甲酯（MCA）；或（3）2毫升生理盐水中含100毫克盐酸喹吖因。福尔马林组和喹吖因组的失败率非常高（分别为60%和75%）。三只接受喹吖因注射的动物意外死亡。MCA组的失败率为40%。与其他两种药剂相比，MCA对局部组织的反应最小。
