Pharmacokinetic considerations of misonidazole in therapeutics.

The pharmacokinetics of misonidazole have been studies in 6 patients with special emphasis on determination of the peak concentration in plasma and saliva. Frequent sampling was performed over 4 h and a marked variation in absorption half-life (range 4-125 min) and time to peak range (0.5-6.5 h) was found. The optimal timing of irradiation is discussed. In addition to a conventional dose, one of the patients received high dose misonidazole; the pharmacokinetics are compared.