Matheson I, Plowman P N, Johnston A
Hum Toxicol. 1984 Feb;3(1):29-36. doi: 10.1177/0960327184003001041.
The pharmacokinetics of misonidazole have been studies in 6 patients with special emphasis on determination of the peak concentration in plasma and saliva. Frequent sampling was performed over 4 h and a marked variation in absorption half-life (range 4-125 min) and time to peak range (0.5-6.5 h) was found. The optimal timing of irradiation is discussed. In addition to a conventional dose, one of the patients received high dose misonidazole; the pharmacokinetics are compared.
已对6名患者进行了米索硝唑的药代动力学研究，特别着重于测定血浆和唾液中的峰值浓度。在4小时内进行了频繁采样，发现吸收半衰期（范围为4 - 125分钟）和达峰时间范围（0.5 - 6.5小时）存在显著差异。讨论了照射的最佳时机。除常规剂量外，其中一名患者接受了高剂量米索硝唑；对两者的药代动力学进行了比较。
