McCredie D A, Troehler U, Bonjour J P
J Lab Clin Med. 1984 Mar;103(3):354-62.
The 47scandium/47calcium ratio technique for studying intestinal absorption of calcium in humans offers the following advantages: neither blood sampling nor complete faecal collection are required, and there is no need for an additional marker or for knowledge of the precise dose of calcium isotope administered. In the study this technique was corrected and modified using a new equation that considerably simplifies the determination procedures. The new method was validated in rats with various intestinal calcium absorption rates. The value of scandium as an unabsorbed intestinal marker was confirmed by the use of 46scandium. A mean recovery of 96% was obtained after intragastric administration. The 47scandium/47calcium ratio technique gave results that correlated well with the faecal 47calcium recovery method over a wide range of intestinal calcium absorption rates obtained by treatment with 1,25-dihydroxycholecalciferol or 1-hydroxyethylidene-1,1-biphosphonate. Taking into account the advantages of the 47scandium/47calcium ratio technique, it appears useful not only in small animals but also in outpatients, particularly children.
用于研究人体肠道钙吸收的47钪/47钙比率技术具有以下优点：既不需要采血，也不需要收集全部粪便，而且无需额外的标记物，也无需知道所给予钙同位素的确切剂量。在该研究中，使用一个大大简化测定程序的新公式对该技术进行了校正和改进。新方法在具有不同肠道钙吸收率的大鼠中得到了验证。通过使用46钪证实了钪作为未吸收的肠道标记物的价值。胃内给药后平均回收率为96%。在通过用1,25 - 二羟胆钙化醇或1 - 羟基亚乙基 - 1,1 - 二膦酸酯处理获得的广泛肠道钙吸收率范围内，47钪/47钙比率技术给出的结果与粪便47钙回收率方法的结果相关性良好。考虑到47钪/47钙比率技术的优点，它不仅在小动物中有用，而且在门诊患者中，特别是儿童中似乎也有用。
