Shinoda J, Iwai T, Hattori T, Kondo H, Sakai N, Yamada H
Gan No Rinsho. 1984 Jan;30(1):53-8.
The effects of radiation therapy with Fluosol-DA on rat mammary tumors were studied. The tissue oxygen tension values of tumors in breathing mixed gas (5% carbon dioxide and 95% oxygen) with Fluosol-DA (25 ml/kg, i.v.) were significantly higher than those in room air without Fluosol-DA. The rats were divided into three groups: Group I received Fluosol-DA but no irradiation, Group II was treated with 1000 rads of irradiation using 60Co without Fluosol-DA in room air and Group III received the same irradiation and Fluosol-DA in breathing mixed gas. In the latter group we observed a prolongation of the survival time and suppression of the tumor growth.
研究了含氟碳代血液（Fluosol - DA）的放射疗法对大鼠乳腺肿瘤的影响。在呼吸含氟碳代血液（25毫升/千克，静脉注射）的混合气体（5%二氧化碳和95%氧气）时，肿瘤组织的氧张力值显著高于在无氟碳代血液的室内空气中的氧张力值。大鼠被分为三组：第一组接受氟碳代血液但不接受照射；第二组在室内空气中不使用氟碳代血液，用60Co进行1000拉德的照射；第三组在呼吸混合气体时接受相同照射并使用氟碳代血液。在后一组中，我们观察到存活时间延长和肿瘤生长受到抑制。
