Gilchrist K W, Uehling D T, Starling J R
J Surg Res. 1984 Mar;36(3):251-5. doi: 10.1016/0022-4804(84)90095-7.
Ureterosigmoidostomy (U-S) is a procedure for diversion of the urinary stream. U-S is associated with a manyfold-increased risk for subsequent development of colonic carcinoma close to the sites of ureteral entry into the sigmoid colon. A surveillance program for colonic carcinomas in U-S patients includes colonoscopic examination of the colon to at least 60 cm and random biopsies of the sigmoid colon distal to the ureteral orifices. In eight patients, a change from sulphomucin to a variable admixture with sialomucin was found in the histologically unremarkable colonic mucosae. When the urinary stream was shunted away from the U-S site in two patients, the mucosal mucin was composed of sulphomucin which is present in normal sigmoid colons. The effect of urine admixed with feces in the sigmoid colon is nonspecific as judged by alterations of the mucosal mucin composition. The U-S patient deserves periodic examinations to detect colonic carcinoma but the histological examination of colonoscopically unremarkable mucosae is not currently contributory toward this surveillance effort.
输尿管乙状结肠吻合术（U-S）是一种用于改道尿液的手术。U-S与输尿管进入乙状结肠部位附近的结肠癌后续发生风险成倍增加相关。对U-S患者的结肠癌监测计划包括对结肠进行至少60厘米的结肠镜检查以及对输尿管口远端的乙状结肠进行随机活检。在8名患者中，在组织学上无异常的结肠黏膜中发现了从硫黏液素到与涎黏液素的可变混合物的变化。当两名患者的尿液从U-S部位分流时，黏膜黏液素由正常乙状结肠中存在的硫黏液素组成。从黏膜黏液素组成的改变判断，乙状结肠中尿液与粪便混合的影响是非特异性的。U-S患者值得定期检查以检测结肠癌，但目前对结肠镜检查无异常的黏膜进行组织学检查对这种监测工作并无帮助。
