Vriend J, Gibbs F P
Life Sci. 1984 Feb 13;34(7):617-23. doi: 10.1016/0024-3205(84)90224-8.
Administration of melatonin via the drinking water prevented the gonadal involution and the thyroid hormone depletion normally observed in blinded hamsters. Ten weeks after blinding male hamsters had plasma thyroxin levels that were 57% of controls and testis weights that were 8% of controls. Administration of melatonin (80 microgram melatonin/ml drinking water) to blinded hamsters restored thyroxin levels to 86% of controls and testis weights to 93% of controls. Dose response data showed that as little as 1.25 microgram (approximately 10 microgram/hamster/day) produced a significant effect on testis weight, whereas the lowest dose required to produce a significant increase in thyroxin levels was 10 microgram/ml. The coincidence of counter-antigonadal and counter-antithyroid actions of melatonin suggests a single site of action.
通过饮用水给予褪黑素可预防通常在致盲仓鼠中观察到的性腺退化和甲状腺激素耗竭。致盲雄性仓鼠10周后，其血浆甲状腺素水平为对照组的57%，睾丸重量为对照组的8%。给致盲仓鼠饮用含褪黑素（80微克褪黑素/毫升饮用水）的水后，甲状腺素水平恢复到对照组的86%，睾丸重量恢复到对照组的93%。剂量反应数据表明，低至1.25微克（约10微克/仓鼠/天）对睾丸重量就有显著影响，而使甲状腺素水平显著升高所需的最低剂量为10微克/毫升。褪黑素的抗性腺和抗甲状腺作用的巧合表明其作用位点单一。
