Navot D, Mor-Yosef S, Granat M, Sadovsky E
Obstet Gynecol. 1984 Mar;63(3):414-7.
Antenatal fetal heart rate monitoring of 20 fetuses with major congenital malformations revealed loss of long-term variability in 11 (55%) and an isolated, abrupt-onset fetal heart rate deceleration in 13 (65%). In ten (50%), loss of variability coexisted with periodic fetal heart rate decelerations. These fetal heart rate changes were significantly more prevalent in the malformed group than in a control population. There was also a significantly increased incidence of fetal distress in labor and in the requirement for primary cesarean section delivery. Perinatal mortality was 75%, reflecting the lethal nature of the malformations. Loss of long-term fetal heart rate variability associated with isolated, abrupt occurrence of fetal heart rate deceleration should raise the possibility of congenital malformations in an apparently normal pregnancy.
对20例患有严重先天性畸形胎儿的产前胎心监护显示，11例（55%）出现长期变异性丧失，13例（65%）出现孤立的、突发的胎心减速。10例（50%）中，变异性丧失与周期性胎心减速并存。这些胎心变化在畸形组中比对照组更为普遍。分娩时胎儿窘迫的发生率以及剖宫产分娩的需求也显著增加。围产期死亡率为75%，反映了畸形的致命性质。与孤立、突发的胎心减速相关的长期胎心变异性丧失应增加看似正常妊娠中存在先天性畸形的可能性。
