Woods J R, Plessinger M A, Mack C E
Pediatr Res. 1984 Jan;18(1):83-5.
Auditory brainstem evoked responses (ABRs) were obtained in utero from five fetal lambs instrumented between 108 and 124 days gestation and tested from 2 to 24 days following surgery. The fetal ABR patterns were then compared with similar ABR measurements from term newborn lambs at 1 day of age. The characteristics of the preterm fetal ABR were dependent upon the period of gestation in which the testing was conducted. The fetal ABR is absent prior to 117 days gestation. The earliest recorded fetal ABR consisted of one or more reproducible deflections and was observable by day 117-125 of gestation. By 126 days gestation the ABR was comparable in waveform pattern to those obtained in one day old term newborn lambs but with delayed peak latencies. The most definitive characteristic of the fetal ABR was the interpeak latency between waves IV and V, which was greater than the interpeak latencies between other wave deflections. Serial recordings of fetal ABRs indicate that latencies to each wave decrease with advancing gestational age. These changes may be suggestive of a maturational process within the auditory system of the developing fetus.
在子宫内对5只妊娠108至124天的胎羊进行仪器植入，并在术后2至24天进行测试，从而获得听觉脑干诱发电位（ABR）。然后将胎儿ABR模式与1日龄足月新生羔羊的类似ABR测量结果进行比较。早产胎儿ABR的特征取决于进行测试时的妊娠期。妊娠117天之前不存在胎儿ABR。最早记录到的胎儿ABR由一个或多个可重复的波峰组成，在妊娠117至125天可观察到。到妊娠126天时，ABR的波形模式与1日龄足月新生羔羊的波形模式相当，但峰潜伏期延迟。胎儿ABR最明确的特征是波IV和波V之间的峰间潜伏期，它大于其他波峰偏转之间的峰间潜伏期。胎儿ABR的系列记录表明，随着胎龄增加，每个波的潜伏期会缩短。这些变化可能暗示发育中胎儿听觉系统内的成熟过程。
