卤虫发育胚胎中的5',5''-P1,P4-四磷酸二腺苷
Diadenosine 5',5'"-P1,P4-tetraphosphate in developing embryos of Artemia.
作者信息
McLennan A G, Prescott M
出版信息
Nucleic Acids Res. 1984 Feb 10;12(3):1609-19. doi: 10.1093/nar/12.3.1609.
Abstract
Diadenosine 5',5'"-P1,P4-tetraphosphate (Ap4A) has been detected in cysts and developing embryos of the brine shrimp Artemia in amounts 10(4)-10(6) times lower than that of the guanine analogue, Gp4G. The unexpectedly high level of Ap4A in dormant cysts of 2.37 pmol/10(6) cells can be reduced to 0.03 pmol/10(6) cells by decapsulation and storage in saturated NaCl. When development is reinitiated, the Ap4A content of the decapsulated embryos undergoes a rapid 125 -fold increase, reaching a maximum of 3.79 pmol/10(6) cells at the point of emergence when DNA replication begins. If replication is delayed by hypoxia, the Ap4A level is adjusted in order to reach the same maximum value when replication finally begins. As replication proceeds, the level of Ap4A declines again. Unlike mammalian cells, Ap4A in Artemia is less metabolically labile than ATP. These results are consistent with the suggested role of Ap4A in the initiation of DNA synthesis.
摘要
在卤虫（Artemia）的囊肿和发育中的胚胎中已检测到5',5''-P1,P4-四磷酸二腺苷（Ap4A），其含量比鸟嘌呤类似物Gp4G低10⁴-10⁶倍。在休眠囊肿中，Ap4A的含量意外地高，为2.37 pmol/10⁶个细胞，通过去壳并储存在饱和氯化钠中，可降至0.03 pmol/10⁶个细胞。当重新开始发育时，去壳胚胎的Ap4A含量迅速增加125倍，在DNA复制开始的孵化点达到最大值3.79 pmol/10⁶个细胞。如果因缺氧而延迟复制，Ap4A水平会进行调整，以便在复制最终开始时达到相同的最大值。随着复制的进行，Ap4A水平再次下降。与哺乳动物细胞不同，卤虫中的Ap4A在代谢上比ATP更稳定。这些结果与Ap4A在DNA合成起始中所起的作用一致。
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