Akiba Y, Takahashi K, Matsumoto T
Poult Sci. 1984 Jan;63(1):117-22. doi: 10.3382/ps.0630117.
The effect of diisopropyl 1,3-dithiolan-2-ylidenemalonate (NKK-100) on experimental fatty livers was investigated in chicks administered an antithyroid agent plus synthetic estrogen or in estrogenized, starved-refed chicks. NKK-100 was added at levels of 250, 500, 1000, and 1500 mg/kg diet. Liver weight was significantly decreased by administration of NKK-100 at 1500 mg/kg diet in the estrogen-administered chicks. Liver lipid content and liver lipid deposition were significantly and inversely decreased with increasing NKK-100 concentration in the diet in the estrogen administered chicks. Plasma transaminase activity, which was elevated by the estrogen administration, was reduced by the administration of NKK-100. These results suggest that NKK-100 may be of value in preventing fatty livers in poultry.
在给雏鸡投喂抗甲状腺药物加合成雌激素或雌激素化、饥饿再投喂的雏鸡中，研究了二异丙基1,3 - 二硫杂环戊烷 - 2 - 亚基丙二酸酯（NKK - 100）对实验性脂肪肝的影响。NKK - 100以250、500、1000和1500 mg/kg饲料的水平添加。在投喂雌激素的雏鸡中，以1500 mg/kg饲料的剂量投喂NKK - 100可显著降低肝脏重量。在投喂雌激素的雏鸡中，随着饲料中NKK - 100浓度的增加，肝脏脂质含量和肝脏脂质沉积显著且呈负相关降低。因投喂雌激素而升高的血浆转氨酶活性，通过投喂NKK - 100而降低。这些结果表明，NKK - 100在预防家禽脂肪肝方面可能具有价值。
