Altura B M, Altura B T, Gebrewold A, Ising H, Günther T
Science. 1984 Mar 23;223(4642):1315-7. doi: 10.1126/science.6701524.
Rats maintained for 12 weeks on diets moderately or more severely deficient in magnesium showed significant elevations in arterial blood pressure compared to control animals. Examination of the mesenteric microcirculation in situ revealed that dietary magnesium deficiency resulted in reduced capillary, postcapillary, and venular blood flow concomitant with reduced terminal arteriolar, precapillary sphincter, and venular lumen sizes. The greater the degree of dietary magnesium deficiency the greater the reductions in microvascular lumen sizes. These findings may provide a rationale for the etiology, as well as treatment, of some forms of hypertensive vascular disease.
与对照动物相比，食用中度或更严重缺镁饮食12周的大鼠动脉血压显著升高。对肠系膜微循环进行原位检查发现，饮食缺镁导致毛细血管、毛细血管后微静脉和小静脉血流量减少，同时终末小动脉、毛细血管前括约肌和小静脉管腔尺寸减小。饮食缺镁程度越高，微血管管腔尺寸减小越明显。这些发现可能为某些形式的高血压血管疾病的病因及治疗提供理论依据。
