Altura B M, Altura B T, Gebrewold A, Ising H, Günther T
Schriftenr Ver Wasser Boden Lufthyg. 1993;88:65-90.
Rats maintained on normal Mg-containing diets for 12 weeks (plasma Mg = 0.96 +/- 0.02 mmole) and subjected to 85 dB(A), 12 h per day for 8 weeks; 95 dB(A), 16 h per day for 4 weeks demonstrated significant elevation in systolic and diastolic arterial blood pressure (ABP); plasma Mg showed a 15% decrease whereas aortic and portal vein muscle exhibited slight reductions in Mg content and elevation in Ca. Moderate (plasma Mg = 0.67 +/- 0.03 mmole) and more severely (plasma Mg = 0.28 +/- 0.01 mmole) Mg deficient animals not subjected to audiogenic stress (AS) also exhibited significant elevations in systolic and diastolic ABP; vascular tissue Mg content decreased whereas Ca content rose. Animals subjected to combined Mg deficiency and AS for 12 weeks exhibited the greatest deficits in plasma and vascular muscle Mg and the greatest elevations in systolic and diastolic ABP; vascular tissue Ca contents also showed the greatest increases. In-situ measurements of mesenteric arterioles, venules and precapillary sphincters in the various subgroups revealed negative correlation between the lumen sizes of these microvessels and plasma Mg. Also, there was an inverse correlation between plasma Mg and ABP. Capillary blood flow transit times were decreased in relation to the degree of plasma Mg reduction. A quantitative rarefication of true capillaries per mesentery was observed. In addition, vascular reactivity of terminal arterioles to constrictor agents (norepinephrine, angiotensin II, Ba2+) was in relation to the plasma and vascular tissue deficit in [Mg]. Reactivity to the dilator agent, histamine, decreased in proportion to Mg deficit. A rationale for therapeutic intervention with Mg may evolve from these studies.
将正常含镁饮食喂养12周（血浆镁 = 0.96 ± 0.02毫摩尔）的大鼠，每天暴露于85分贝(A)环境12小时，持续8周；或暴露于95分贝(A)环境16小时，持续4周，结果显示收缩压和舒张压显著升高；血浆镁含量下降了15%，而主动脉和门静脉肌肉的镁含量略有降低，钙含量升高。未遭受声源性应激（AS）的中度（血浆镁 = 0.67 ± 0.03毫摩尔）和重度（血浆镁 = 0.28 ± 0.01毫摩尔）镁缺乏动物的收缩压和舒张压也显著升高；血管组织镁含量下降，而钙含量上升。同时遭受镁缺乏和AS 12周的动物，血浆和血管肌肉中的镁缺乏最为严重，收缩压和舒张压升高幅度最大；血管组织钙含量增加也最为显著。对各个亚组的肠系膜小动脉、小静脉和毛细血管前括约肌进行原位测量发现，这些微血管的管腔大小与血浆镁之间呈负相关。此外，血浆镁与血压也呈负相关。毛细血管血流通过时间随血浆镁降低程度而缩短。观察到每肠系膜真毛细血管数量有所减少。此外，终末小动脉对收缩剂（去甲肾上腺素、血管紧张素II、Ba2+）的血管反应性与血浆和血管组织中镁的缺乏有关。对舒张剂组胺的反应性则随镁缺乏程度成比例降低。这些研究可能会为镁的治疗干预提供理论依据。
