[γ射线辐照与5-溴脱氧尿苷对人类染色体的联合作用]
[Combined action of gamma irradiation and 5-bromodeoxyuridine on human chromosomes].
作者信息
Sapacheva V A
出版信息
Tsitol Genet. 1984 Jan-Feb;18(1):50-4.
PMID:6701965
Abstract
A combined effect has been studied of 5-bromo-deoxyuridine (BDU) and gamma-radiation on human lymphocytes at the G0 stage. BDU is shown to induce chromatid aberrations irrespective of its radiation. The frequency of chromatid aberrations rises with the BDU concentration. BDU modifies the effect of gamma-radiation on human lymphocytes at the G0 stage, increasing the number of chromosome aberrations. BDU slows down the lymphocyte cell cycle.
摘要
研究了5-溴脱氧尿苷（BDU）和γ辐射对处于G0期的人淋巴细胞的联合效应。结果表明，无论是否存在辐射，BDU均可诱导染色单体畸变。染色单体畸变的频率随BDU浓度的增加而升高。BDU改变了γ辐射对处于G0期的人淋巴细胞的效应，增加了染色体畸变的数量。BDU减缓了淋巴细胞的细胞周期。
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