Tsaritsinskiĭ V I
Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84(1):92-8.
Patients with paranoid schizophrenia display fully or partially unstable circadian rhythms. A comparison of three regimens of haloperidol administration shows that the generally accepted therapeutic mode with this drug (thrice daily) should be modified. A once a day administration scheme proves to be more effective. Patients with a partial instability of the circadian rhythms should be given the drug in the morning and those with complete instability in the evening since this regimen employing a lower daily dose of this neuroleptic and associated with fewer side effects ensures more pronounced and prolonged remissions occurring at a faster rate.
偏执型精神分裂症患者表现出完全或部分不稳定的昼夜节律。对三种氟哌啶醇给药方案的比较表明，这种药物普遍接受的治疗方式（每日三次）应予以调整。每日一次的给药方案被证明更有效。昼夜节律部分不稳定的患者应在早晨给药，而昼夜节律完全不稳定的患者应在晚上给药，因为这种方案使用较低剂量的这种抗精神病药物且副作用较少，可确保更快地出现更显著和持久的缓解。
