Saretok T, Almersjö O, Biber B, Gustavsson B, Hasselgren P O
Acta Chir Scand. 1984;150(1):1-4.
The effects on liver blood flow caused by hydralazine were studied in 14 dogs. Hepatic artery and femoral artery blood flow were estimated with an electromagnetic flow meter. Total hepatic blood flow (THBF) was measured by 133Xenon clearance. Cardiac output (CO) was determined by intravenous injection of Cardio-Green. After 0.2 mg/kg of hydralazine total hepatic blood flow increased by 57%. The hepatic artery blood flow increased by 82% and portal blood flow by 58%. Cardiac output increased by about 50%, while total peripheral vascular resistance decreased. The results further suggest that hydralazine increases portal blood flow. Also the ratio THBF : CO increased. These findings together indicate a hydralazine-induced redistribution of cardiac output with a relatively increased proportion provided to the liver.
在14只犬中研究了肼屈嗪对肝血流量的影响。用电磁流量计估计肝动脉和股动脉血流量。通过133氙清除法测量肝总血流量（THBF）。通过静脉注射心脏绿来测定心输出量（CO）。给予0.2mg/kg肼屈嗪后，肝总血流量增加了57%。肝动脉血流量增加了82%，门静脉血流量增加了58%。心输出量增加了约50%，而总外周血管阻力降低。结果进一步表明肼屈嗪可增加门静脉血流量。此外，THBF:CO比值增加。这些发现共同表明肼屈嗪引起心输出量重新分布，相对增加了供应给肝脏的比例。
