Daniels S, Iskandrian A S, Hakki A H, Kane S A, Bemis C E, Horowitz L N, Greenspan A M, Segal B L
Am Heart J. 1984 Apr;107(4):711-7. doi: 10.1016/0002-8703(84)90319-3.
To examine the Brody effect in humans, we studied 15 patients by means of coronary sinus pacing. We measured left ventricular (LV) volumes from the cardiac output (measured by the thermodilution technique) and LV ejection fraction (measured by radionuclide ventriculography). Pulmonary blood volume was determined by means of cardiac output and mean pulmonary transit time. In six patients, pacing was performed at two different rates, resulting in 21 pacing measurements. The heart rate increased with pacing from 73 +/- 11 to 119 +/- 19 bpm (mean +/- standard deviation, p less than 0.001). The end-diastolic volume (EDV) and the end-systolic volume (ESV) decreased with pacing (p less than 0.001 each). The R wave amplitude decreased with pacing (1.44 +/- 0.63 mV control vs 1.32 +/- 0.58 mV with pacing; p less than 0.01). R wave amplitude decreased in 19 of the 21 pacing studies (90%); EDV and ESV decreased in all 21 pacing studies, and pulmonary blood volume decreased in 14 of the 15 pacing studies (93%) performed in 11 patients. There was a significant correlation between the percentage of change in R wave amplitude with the percentage of change in EDV (r = 0.54, p less than 0.01) and with the percentage of change in ESV (r = 0.54, p less than 0.01). These results, therefore, validate Brody's hypothesis and indicate that changes in LV volumes affect the R wave amplitude.
为了研究人体中的布罗迪效应，我们通过冠状窦起搏对15名患者进行了研究。我们通过心输出量（采用热稀释技术测量）和左心室射血分数（采用放射性核素心室造影测量）来测量左心室（LV）容积。肺血容量通过心输出量和平均肺 transit 时间来确定。在6名患者中，以两种不同的速率进行起搏，共进行了21次起搏测量。随着起搏，心率从73±11次/分钟增加到119±19次/分钟（平均值±标准差，p<0.001）。舒张末期容积（EDV）和收缩末期容积（ESV）随着起搏而减小（各p<0.001）。R波振幅随着起搏而减小（对照时为1.44±0.63mV，起搏时为1.32±0.58mV；p<0.01）。在21次起搏研究中的19次（90%），R波振幅减小；在所有21次起搏研究中，EDV和ESV均减小，在11名患者进行的15次起搏研究中的14次（93%），肺血容量减小。R波振幅变化百分比与EDV变化百分比（r = 0.54，p<0.01）以及与ESV变化百分比（r = 0.54，p<0.01）之间存在显著相关性。因此，这些结果验证了布罗迪的假设，并表明左心室容积的变化会影响R波振幅。
