Adeyokunnu A A
Am J Dis Child. 1984 Apr;138(4):346-8. doi: 10.1001/archpedi.1984.02140420012005.
Five patients with radial aplasia studied during a period of ten years at the University College Hospital, Ibadan, Nigeria, had the amegakaryocytic thrombocytopenia syndrome. Together, they are termed the TAR syndrome. Two of the five patients were siblings from a polygamous family; three patients had relative hypogammaglobulinemia, and one of these patients had late onset of congenital varicella. The findings in these five cases led to further understanding of the genetic mechanisms of the TAR syndrome. Furthermore, the high incidence of infection associated with the syndrome could be partially explained by hypogammaglobulinemia.
在尼日利亚伊巴丹大学学院医院为期十年的研究期间，对五名患有桡骨发育不全的患者进行了研究，他们患有无巨核细胞性血小板减少综合征。他们合称为TAR综合征。五名患者中有两名是来自一夫多妻制家庭的兄弟姐妹；三名患者有相对低丙种球蛋白血症，其中一名患者先天性水痘发病较晚。这五个病例的研究结果有助于进一步了解TAR综合征的遗传机制。此外，该综合征相关感染的高发病率部分可由低丙种球蛋白血症来解释。
