Sculier J P, Klastersky J
Am J Med. 1984 Mar;76(3):429-35. doi: 10.1016/0002-9343(84)90662-4.
Serum bactericidal activity was determined routinely in 89 patients with gram-negative bacillary bacteremia, 79 of whom were analyzed because they had granulocyte counts either below 100/mm3 or above 1,000/mm3. A peak (one hour after the administration of the antibiotics) serum bactericidal titer of 1:8 or more in non-granulocytopenic patients or 1:16 or more in severely granulocytopenic patients could be correlated with a favorable clinical response, in 98 percent (44 of 45) (p less than 0.0001) and 87 percent (20 of 23), (p less than 0.001) respectively. Granulocytopenic patients required a statistically significantly higher serum bactericidal activity for a favorable response. Serum bactericidal activity appears to be a useful and simple method to monitor antibiotic treatment in gram-negative bacillary bacteremia, especially when combination therapy is used.
对89例革兰氏阴性杆菌菌血症患者常规测定血清杀菌活性，其中79例因粒细胞计数低于100/mm³或高于1000/mm³而进行分析。非粒细胞减少患者抗生素给药后1小时血清杀菌效价峰值达到1:8或更高，严重粒细胞减少患者达到1:16或更高，分别与98%（45例中的44例）（p<0.0001）和87%（23例中的20例）（p<0.001）的良好临床反应相关。粒细胞减少患者需要统计学上显著更高的血清杀菌活性才能获得良好反应。血清杀菌活性似乎是监测革兰氏阴性杆菌菌血症抗生素治疗的一种有用且简单的方法，尤其是在使用联合治疗时。
