Summer T L, Ferraro J S, McCormack C E
Am J Physiol. 1984 Mar;246(3 Pt 2):R299-304. doi: 10.1152/ajpregu.1984.246.3.R299.
A phase-response curve (PRC) for the circadian rhythm of locomotor activity was constructed for female Sprague-Dawley-derived rats kept in continuous darkness (DD) except when given a 1-h light pulse (150 lx) once each 2 wk. By use of the circadian onset of wheel running as the phase-reference point, the free-running period (tau) in DD was 24.09 h. Maximum phase delays and phase advances occurred in response to light pulses given during the first 5 and last 6 h of activity, respectively. The delay-to-advance ratio (D/A) of the PRC was 1.5. In a separate group of rats exposed to continuous light, tau increased by 1.45 h as illuminance was increased in log steps from 0.1 to 10 lx, thus demonstrating the Aschoff effect in rats. This increase in tau was large, considering the relatively low D/A of the PRC, suggesting that factors in addition to the D/A contribute to the Aschoff effect.
为雌性斯普拉格-道利衍生大鼠构建了运动活动昼夜节律的相位响应曲线（PRC）。这些大鼠饲养在持续黑暗（DD）环境中，每2周给予一次1小时的光脉冲（150勒克斯）。以转轮活动的昼夜起始点作为相位参考点，DD条件下的自由运行周期（tau）为24.09小时。最大相位延迟和相位提前分别出现在活动的前5小时和后6小时给予光脉冲时。PRC的延迟与提前比（D/A）为1.5。在另一组暴露于持续光照的大鼠中，随着光照强度以对数步长从0.1勒克斯增加到10勒克斯，tau增加了1.45小时，从而在大鼠中证明了阿绍夫效应。考虑到PRC相对较低的D/A，tau的这种增加幅度较大，表明除了D/A之外的因素也促成了阿绍夫效应。
