Waechter F, Bieri F, Stäubli W, Bentley P
Biochem Pharmacol. 1984 Jan 1;33(1):31-4. doi: 10.1016/0006-2952(84)90366-6.
The repeated oral administration of nafenopin, a hypolipidaemic compound, at a dose of 100 mg/kg to male C57BL/6, DBA/2, Balb c and C3H mice caused an increase in the specific activity of liver cytosolic epoxide hydrolase, the activity of microsomal epoxide hydrolase was also increased in all except the C3H mice. The dose dependence and the specificity of this induction was investigated in male DBA/2 mice. In the range of 10-200 mg/kg nafenopin the induction of the two hydrolase activities was found to increase with increasing doses of the test compound. Two other cytosolic enzyme activities, lactate dehydrogenase and glutathione S-transferase, remained essentially unchanged within the dose range investigated.
给雄性C57BL/6、DBA/2、Balb c和C3H小鼠反复口服剂量为100 mg/kg的降脂化合物萘苯丁酸，导致肝脏胞质环氧化物水解酶的比活性增加，除C3H小鼠外，所有小鼠微粒体环氧化物水解酶的活性也增加。在雄性DBA/2小鼠中研究了这种诱导的剂量依赖性和特异性。在10-200 mg/kg萘苯丁酸范围内，发现两种水解酶活性的诱导随着受试化合物剂量的增加而增加。另外两种胞质酶活性，即乳酸脱氢酶和谷胱甘肽S-转移酶，在所研究的剂量范围内基本保持不变。
