Gibbs M E, Ng K T
Behav Brain Res. 1984 Feb;11(2):103-8. doi: 10.1016/0166-4328(84)90132-3.
Diphenylhydantoin was shown to extend the duration of maximum availability of both short-term and intermediate memory in day-old chicks following a single trial passive avoidance learning task. Diphenylhydantoin also extended the time of susceptibility of long-term memory to inhibition by cyloheximide, suggesting that the extention of the life of intermediate memory was accompanied by a delay in long-term memory formation. Furthermore, while diphenylhydantoin counteracted amnesia induced by cycloheximide given 5 min before or immediately after learning, it had no effect on amnesia induced by cycloheximide administered 5 min or later after learning. For the latter, a second injection of diphenylhydantoin was necessary. This is consistent with the argument that the first injection of diphenylhydantoin extended the life of intermediate memory and delayed the formation of long-term memory.
在一日龄雏鸡单次被动回避学习任务后，已证明苯妥英可延长短期和中期记忆的最大可利用时长。苯妥英还延长了长期记忆对放线菌酮抑制作用的敏感时间，这表明中期记忆寿命的延长伴随着长期记忆形成的延迟。此外，虽然苯妥英能抵消在学习前5分钟或学习后立即给予的放线菌酮所诱导的失忆，但对学习后5分钟或更晚给予的放线菌酮所诱导的失忆没有影响。对于后者，需要第二次注射苯妥英。这与首次注射苯妥英延长了中期记忆寿命并延迟了长期记忆形成的观点一致。
