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[来自接受广泛肠道切除术大鼠的淋巴细胞对“再生”信息的传递]

[Transmission of "regenerative" information by lymphocytes from rats with extensive intestinal resections].

作者信息

Timashkevich T V, Kharlova G V, Iudina N V

出版信息

Biull Eksp Biol Med. 1984 Mar;97(3):352-3.

PMID:6704532
Abstract

Lymphocytes from male F1 rats (August X black Wistar) with a resected half of the small intestine (10 cm after stomach) are capable to stimulate the mitotic activity in the epithelium of small intestinal and esophageal crypts in syngeneic recipients. The correlation of the mitotic phases in experimental animals remained unchanged whereas the number of cells in experimental recipients' crypts significantly increased, thereby attesting to genuine stimulation of the proliferation. Lymphocytes from sham-operated rats failed to demonstrate such a property. In control recipients the mitotic index and the cell number in the crypt of the control recipients did not differ significantly from the appropriate characteristics in intact rats of the same age.

摘要

切除一半小肠(胃后10厘米处)的雄性F1大鼠(奥古斯特×黑色Wistar)的淋巴细胞,能够刺激同基因受体小肠和食管隐窝上皮细胞的有丝分裂活性。实验动物有丝分裂期的相关性保持不变,而实验受体隐窝中的细胞数量显著增加,从而证明了增殖受到了真正的刺激。假手术大鼠的淋巴细胞未表现出这种特性。在对照受体中,对照受体隐窝中的有丝分裂指数和细胞数量与同年龄完整大鼠的相应特征相比,无显著差异。

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Biull Eksp Biol Med. 1984 Mar;97(3):352-3.
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