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Formation of O6-methylguanine in regenerating rat liver by N-nitrosomethylbenzylamine is not sufficient for initiation of preneoplastic foci.

作者信息

Silinskas K C, Zucker P F, Labuc G E, Archer M C

出版信息

Carcinogenesis. 1984 Apr;5(4):541-2. doi: 10.1093/carcin/5.4.541.

DOI:10.1093/carcin/5.4.541
PMID:6705151
Abstract

The DNA methylating activities of N-nitrosodimethylamine (NDMA), an initiator of hepatic gamma-glutamyltranspeptidase-positive foci, and N-nitrosomethylbenzylamine (NMBzA), which does not initiate, were studied in regenerating rat liver. Equimolar doses of 14C-labelled NDMA and NMBzA (33.5 mumol/kg) were administered to male Sprague-Dawley rats 18 h after partial hepatectomy. NDMA and NMBzA both produced 7-methylguanine and O6-methylguanine. The results suggest that although the formation of O6-methylguanine may be necessary it is not sufficient for initiation of preneoplastic foci.

摘要

相似文献

1
Formation of O6-methylguanine in regenerating rat liver by N-nitrosomethylbenzylamine is not sufficient for initiation of preneoplastic foci.
Carcinogenesis. 1984 Apr;5(4):541-2. doi: 10.1093/carcin/5.4.541.
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