Nakagawa T, Yoshinoya S, Sakamoto Y, Ito K, Miyamoto T
Clin Allergy. 1984 Mar;14(2):129-38. doi: 10.1111/j.1365-2222.1984.tb02643.x.
Sera from forty patients with house-dust-mite-sensitive bronchial asthma were examined for the presence of circulating immune complexes (CIC) by the sensitive and quantitative Clq solid-phase radioimmunoassay (Clq-SP) and a monoclonal rheumatoid factor solid-phase radioimmunoassay (mRF-SP). Compared to fifteen normal individuals, the asthmatic patients showed significantly higher mean values of Clq-reactive materials; however, there was no difference between the results from the patients treated by immunotherapy using Dermatophagoides farinae extract and those not so treated. Moreover, immune complexes in eight patients before and after immunotherapy showed that the amount of the complexes tend to decrease during immunotherapy. Furthermore, the presence of complexes had no relationship with the amounts of mite-specific IgG antibody. Similar results were also obtained in tests using mRF-SP. These data suggest that complexes in the sera of the house-dust-mite-sensitive asthmatic patients are not necessarily associated either with immunotherapy or with the mite-specific IgG antibodies.
采用敏感定量的Clq固相放射免疫分析法（Clq-SP）和单克隆类风湿因子固相放射免疫分析法（mRF-SP），检测了40例对屋尘螨敏感的支气管哮喘患者血清中循环免疫复合物（CIC）的存在情况。与15名正常个体相比，哮喘患者的Clq反应性物质平均值显著更高；然而，使用粉尘螨提取物进行免疫治疗的患者和未接受该治疗的患者的检测结果并无差异。此外，8例患者在免疫治疗前后的免疫复合物情况显示，免疫治疗期间复合物数量有减少趋势。此外，复合物的存在与螨特异性IgG抗体的量无关。使用mRF-SP检测也得到了类似结果。这些数据表明，对屋尘螨敏感的哮喘患者血清中的复合物不一定与免疫治疗或螨特异性IgG抗体相关。
