皮肤中检测嵌合体的问题。一例8号三体嵌合体病例说明原位组织培养的优势。
Problems of detecting mosaicism in skin. A case of trisomy 8 mosaicism illustrating the advantages of in situ tissue culture.
作者信息
Procter S E, Watt J L, Lloyd D J, Duffty P
出版信息
Clin Genet. 1984 Mar;25(3):273-7. doi: 10.1111/j.1399-0004.1984.tb01989.x.
Abstract
A case of mosaic trisomy 8 is described and the accuracy of flask culture and in situ culture techniques in detecting chromosomal mosaicism in tissues discussed. The advantages of the in situ method are illustrated and the importance of mixed colonies in defining mosaicism highlighted. The implications for prenatal diagnosis of mosaicism are pointed out.
摘要
本文描述了一例8号染色体嵌合三体病例，并讨论了培养瓶培养和原位培养技术在检测组织中染色体嵌合现象方面的准确性。阐述了原位方法的优点，并强调了混合集落在定义嵌合现象中的重要性。指出了嵌合现象对产前诊断的影响。
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