Romano S, Pozzoni L, Beltrami A, Calosso E, Martinelli C, Verzoni A, Croce L
G Ital Cardiol. 1984 Jan;14(1):16-21.
The aim of this study was to establish the electrophysiological mechanism of atrial pauses, defined as a sudden lengthening of atrial cycle greater than or equal to 10% of its basal value. The sinus node electrogram (SNE) was recorded during electrophysiological study in 20 subjects. Satisfactory recordings of 64 pauses were obtained, 25 of which were spontaneous, 16 were induced by short periods of atrial pacing (AP) in normal subjects, whereas 23 atrial pauses were induced with the premature stimulation method. The basal sinus cycle and the one during the spontaneous pauses were measured from the upstroke slope on the SNE. The electrically induced pauses of the sinus cycle were measured from the artifact of the stimulus to the upstroke slope of the SNE of the first post-pacing beat. We have found that: 1-spontaneous atrial pauses correspond to a moderate slowing of the sinus cycle and to a depression of the sinoatrial conduction occasionally up to a second degree sinoatrial block. Only in subjects with sick sinus disease, the atrial pauses are induced by depression of the sinus automatism; 2-in normal subjects the AP results in a sinoatrial conduction delay; 3-the single extrastimulus regularly produces a moderate increase of the sinoatrial conduction time with variable but minimal effects on the sinus node automatism.
本研究的目的是确定心房停搏的电生理机制,心房停搏定义为心房周期突然延长且延长幅度大于或等于其基础值的10%。在20名受试者的电生理研究过程中记录了窦房结电图(SNE)。共获得64次停搏的满意记录,其中25次为自发性停搏,16次是由正常受试者短时间心房起搏(AP)诱发的,而23次心房停搏是用早搏刺激法诱发的。基础窦性周期和自发性停搏期间的窦性周期是根据SNE上的上升斜率来测量的。电诱发的窦性周期停搏是从刺激伪差到起搏后第一个心动周期SNE的上升斜率来测量的。我们发现:1. 自发性心房停搏对应于窦性周期的中度减慢以及窦房传导的抑制,偶尔可达二度窦房阻滞。仅在病态窦房结综合征患者中,心房停搏是由窦房结自律性降低诱发的;2. 在正常受试者中,心房起搏会导致窦房传导延迟;3. 单个期外刺激通常会使窦房传导时间适度延长,对窦房结自律性有可变但极小影响。