盐酸对氯硝西泮、氟硝西泮和硝西泮的水解作用。一些其他产物的鉴定。
Hydrolysis of clonazepam, flunitrazepam and nitrazepam by hydrochloric acid. Identification of some additional products.
作者信息
de Bruyne M M, Sinnema A, Verweij A M
出版信息
Forensic Sci Int. 1984 Feb;24(2):125-35. doi: 10.1016/0379-0738(84)90092-6.
PMID:6706262
Abstract
Several by-products in the hydrochloric acid hydrolysis of clonazepam, flunitrazepam and nitrazepam are isolated by a combination of TLC and HPLC. With mass and NMR spectroscopic methods the structures of the by-products are established. Some indications are given for possible modes of formation of the by-products.
摘要
通过薄层色谱法（TLC）和高效液相色谱法（HPLC）相结合的方法，分离出了氯硝西泮、氟硝西泮和硝西泮在盐酸水解过程中的几种副产物。利用质谱和核磁共振光谱方法确定了这些副产物的结构。给出了一些关于副产物可能形成方式的线索。
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