Jaffe M, Borochowitz Z, Dar H
Isr J Med Sci. 1984 Feb;20(2):136-40.
The clinical and laboratory investigation of the etiology of mental retardation is discussed. By clinically determining the stage of onset of the mental retardation, it is possible to dispense with a large number of special investigations. It is concluded that the laboratory is chiefly of value in confirming clinical suspicions, and that only rarely will random or routine testing yield an unexpected diagnosis. The possible exception is dermatoglyphic analysis in nondysmorphic, idiopathically retarded patients. This examination demonstrated probable antenatal causative factors in a high percentage of children with retardation of intrauterine origin. If further investigation were to confirm the findings, then this simple examination should be included in the routine evaluation of these cases.
本文讨论了智力发育迟缓病因的临床及实验室检查。通过临床确定智力发育迟缓的发病阶段，有可能省去大量特殊检查。得出的结论是，实验室检查主要价值在于证实临床怀疑，随机或常规检测很少能得出意外诊断。可能的例外是对无畸形、特发性智力发育迟缓患者的皮纹分析。这项检查在高比例的宫内起源智力发育迟缓儿童中显示出可能的产前致病因素。如果进一步调查证实这些发现，那么这项简单检查应纳入这些病例的常规评估。
